An injury can change the trajectory of somebody’s career. For example, Dwayne Johnson had dreams of gridiron stardom that were derailed by a football injury. And Rob Lowe lost out on what could have been a major breakout role in the ’80s because of, well, a Footloose injury. While that literal misstep didn’t keep Lowe from becoming a star, he admits he was a little disappointed in how the episode played out. (Click on the media bar below to hear Rob Lowe)