NUP_144555_0383.jpg Christina Applegate, whose early acting career featured a storied run on Married with Children, must have been a bit heartbroken when the critically acclaimed sitcom Samantha Who? was unceremoniously canceled by ABC.

Now she’s back with Will Arnett (co-star of the short-lived sitcom Running Wilde) in Up All Night, as they play a married couple who are a bit overwhelmed by parenthood.

During the NBC TCA sessions, Applegate explains why it was a bit detrimental to take two and a half years off from acting (this was before she landed the lead in Samantha Who?):

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Up All Night, co-starring Maya Rudolph, premieres September 14th (NBC, 10 pm et/pt).

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