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Premiering September 14th (NBC, 10 pm et/pt), the freshman series Up All Night centers on Reagan (Christina Applegate) a career woman whose husband Chris (Will Arnett) is a stay at home dad.  The couple still believe their baby won’t drastically change their social lives, but sleep deprivation and reality eventually sets in.  Maya Rudolph also stars as Reagan’s boss, a talk show host who adds to the new mom’s complicated life.

Click on the media bar and listen to Applegate, who starred in the TV series Married With Children and Samantha Who?, talk about her new show.

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