Lifetime Networks has lined up a powerful group of A-listers to direct the Lifetime original movie Project Five.

Jennifer Aniston, Alicia Keys, Demi Moore and Independent Spirit Award-winner Patty Jenkins (Monster) have been signed to direct the project, which is an anthology of five short films exploring the impact of breast cancer on people’s lives.

Aniston, Marta Kauffman (Friends), Paula Wagner (Mission: Impossible), Kristin Hahn (The Departed), Kevin Chinoy and Francesca Silvestri (Greg the Bunny) will executive produce the production. Project Five reunites Aniston and Kauffman for the first time since Friends.

Project Five will use humor and drama to highlight the effect that the disease has on relationships along with the way women perceive themselves - all while searching for strength, comfort, medical breakthroughs and, of course, a cure.