Rosie O’Donnell is jumping back into the talk show game - on satellite radio.

Starting this fall, the energetic and outspoken O’Donnell will host a two-hour daily show called “Rosie Radio” on Sirius XM, 10 a.m.-noon.

“Rosie Radio” is being billed as a lifestyle show, which like her former TV talk show is designed to blend “humor, pop culture and serious conversation.” She will have celebrity guests and take listener calls.

Besides marking O’Donnell’s return to the daily talk biz, this move is also clearly designed to send a message about Sirius XM’s faith in its future.

Since Sirius and XM merged, the combined company has suffered from a depressed stock price and subscriber growth stagnation fueled by the slumping auto market.

Signing a new talent as high-profile as O’Donnell says the company intends to remain an aggressive player in the media game.

O’Donnell joins a Sirius XM lineup of “lifestyle” hosts that also includes Oprah and Martha Stewart. It also makes puts her in the same lineup with Howard Stern – the Sirius XM morning host who feuded with O’Donnell for years before they recently had some conciliatory exchanges.